DESCRIPTION
Melanotan 2 is a superpotent melanocortin analog developed to overcome the rapid enzymatic degradation of natural $alpha$-MSH. Through rational drug design, the inclusion of D-Phenylalanine (D-Phe) at position 7 and the formation of a covalent lactam bridge between Aspartic Acid (residue 5) and Lysine (residue 10) constrain the peptide into a rigid beta-turn conformation.
This structural modification significantly increases its binding affinity (Ki) across multiple melanocortin receptor subtypes, specifically MC1R (pigmentation) and MC4R (energy homeostasis and neuro-signaling).
In the research context, Melanotan 2 serves as a critical probe for mapping the central melanocortin system. It is extensively utilized to study the pathophysiology of energy balance, the regulation of tyrosinase activity in melanocytes, and the hemodynamic effects of sympathomimetic activation. Due to its ability to cross the blood-brain barrier in animal models, it remains a primary tool for investigating neuro-mediated physiological responses.
This product is supplied by Vitalyx Research strictly research use only.
- Not intended for human or animal use
- Not approved by the U.S. Food and Drug Administration (FDA)
- Not intended to diagnose, treat, cure, or prevent any disease
All information provided is for educational and scientific reference purposes only.
Vitalyx Research operates exclusively as a chemical supplier and does not provide medical or clinical guidance.
Reviews
There are no reviews yet.